The C3 Church


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C3 and C5 convertases are central stages of the complement cascade since they converge the different initiation pathways, augment complement activation by an amplification loop and lead to a common terminal pathway resulting in the formation of the membrane attack complex. Several complement inhibitors attenuate convertase formation and/or.


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The C3 convertase cleaves C3 to give C3a (9 kDa) and C3b (185 kDa). In the presence of excess C3b, C5 is also a substrate for the enzyme [11]. The C5 convertase of the classical complement pathway is thus a protein complex consisting of C4b, C2a and C3b [12]. Within this complex, C3b binds to C4b via an ester linkage to Ser1217 of C4b [13].


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Abstract. C3 and C5 convertases are central stages of the complement cascade since they converge the different initiation pathways, augment complement activation by an amplification loop and lead to a common terminal pathway resulting in the formation of the membrane attack complex. Several complement inhibitors attenuate convertase formation.


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Dysregulation of the complement cascade is thought to be instrumental for AMD pathophysiology. In particular, C3 and C5 are pivotal components of the complement cascade and have become leading therapeutic targets for AMD. In this article, we discuss C3 and C5 in detail, including their roles in AMD, biochemical and structural aspects, locations.


The C3 Church

Complement proteins, including C3 and C5, are typically produced in the liver, then enter the circulation and can deposit within various tissues. Of note, extrahepatic C3 or C5 expression by both myeloid and non-myeloid cell types has also been described in many tissues, disease models and pathophysiological contexts (Reis et al., 2006).


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Complement convertases mediate C3 and C5 conversion. (A) Upon complement activation, C3 convertases consisting of either C4b2a (CP and LP) or (B) C3bBb [alternative pathway (AP)] form on the cell surface. Conversion of C3 results in deposition of C3b molecules via the thioester (red dot), which form the basis for new AP convertases (amplification loop) or associate with existing C3 convertases.


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Synonyms: Vertebrae C1-C7. The cervical portion of the spine is an important one anatomically and clinically. It is within this region that the nerves to the arms arise via the brachial plexus, and where the cervical plexus forms providing innervation to the diaphragm among other structures. The cervical spine also allows passage of important.


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C5. The cervical spine consists of seven vertebrae and is located at the base of the skull. Its function is to support the skull, enabling head movements back and forth, and from side to side, as.


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Cervical nerves are spinal nerves that arise from the cervical region of the spinal cord. These nerves conduct motor and sensory information via efferent and afferent fibers, respectively, to and from the central nervous system. While classified as peripheral nerves, the motor cell body resides in the anterior horn of the spinal cord. There are eight pairs of cervical nerves, denoted C1 to C8.


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Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the complement system of vertebrate animals and contributes to innate immunity.In humans it is encoded on chromosome 19 by a gene called C3.. Deficiencies and defects of C3 result in the affected person being immunocompromised and particularly.


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Here are some symptoms that patients may begin experiencing due to the degenerative disc disease and cervical foraminal stenosis: Acute or chronic neck pain. Pain that radiates into the arms. Numbness and/or tingling in the arm. Weakness in specific muscles of the arm. When foraminal stenosis occurs higher in the neck, C3-C4 foraminal stenosis.


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The C3, C4, and C5 vertebrae form the midsection of the cervical spine, near the base of the neck.A cervical vertebrae injury is the most severe of all spinal cord injuries because the higher up in the spine an injury occurs, the more damage that is caused to the central nervous system. Depending on the severity of the damage to the spinal cord, the injury may be noted as complete or incomplete.


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C3 conversion takes place in the fluid phase and on surfaces (even at low C3b deposition), whereas efficient C5 conversion happens on surfaces with a dense deposition of C3b as Berends et al have shown. 30,33 Zwarthoff et al concluded that C5 interacts with C3b at the MG4-MG5 site on C3b similarly to what is proposed for C3. 32-34 However.


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The C5 vertebra is at a higher risk of stenosis occurring from birth compared to the other vertebrae in C2-C5 motion segments. 3 Binder AI. Cervical spondylosis and neck pain. BMJ. 2007;334(7592):527-31. Fracture. The vertebrae from C2 through C5 may fracture or dislocate as a result of trauma from falls, motor vehicle accidents, or whiplash.